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NeuroscienceLetters, 140(1992)141 147 141 1992ElsevierScientificPublishersIrelandLtd.All rightsreserved0304-3940/92/$05.00
 

Summary: NeuroscienceLetters, 140(1992)141 147 141
1992ElsevierScientificPublishersIrelandLtd.All rightsreserved0304-3940/92/$05.00
NSL 08687
Persistent pain inhibits contralateral somatosensory cortical activity in
humans
A. Vania Apkarian a, Richard A. Stea a, Stephen H. Manglos b, Nikolaus M. Szeverenyib, Robert B. King a and
F. Deaver Thomas b
ODepartmentof Neurosurgeryand bDepartmentof Radiology, SUN Y Health ScienceCenter,SyracuseNY 13210 (USA)
(Received12December1991;Revisedversionreceived2 March 1992;Accepted10March 1992)
Key words: Pain;Cerebralblood flow;SPECT;HMPAO;Corticalinhibition;Functionalimaging;Human
Toassesscorticalactivityduringpain perception,regionalcerebralblood flow(rCBF)studiesweredonein humansusingsinglephoton emission
computedtomography(SPECT)withthe radiotracerTc99m-HMPAOand magneticresonanceimaginglocalization.NormalizedSPECTdata were
analyzedbyregionofinterestand changedistribution.ContralateralsomatosensoryrCBF wasdecreasedwhenthedigitsofthe hand wereimmersed
ina hotwaterbath for3minwhichwasratedasmoderatelypainful(persistentpain).No decreasewasobservedwhenthehandwasimmersedin tepid
water(control).Incontrast,corticalrCBF wasincreasedduringvibratoryand sensorimotortasks,in thecontralateralsomatosensoryand sensorimo-
tor areas, respectively.Theseresultsindicatethat painperceptionin man is associatedwithsomatosensorycorticalinhibition.
Identifying neural elements that participate in pain
perception is critical in designing appropriate diagnostic
and treatment approaches for chronic pain which is the
most frequent cause of disability in the United States

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine