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Increased metabolic rate and insulin sensitivity in male mice lacking the carcino-embryonic antigen-related cell adhesion
 

Summary: ARTICLE
Increased metabolic rate and insulin sensitivity in male mice
lacking the carcino-embryonic antigen-related cell adhesion
molecule 2
P. R. Patel & S. K. Ramakrishnan & M. K. Kaw & C. K. Raphael & S. Ghosh &
J. S. Marino & G. Heinrich & S. J. Lee & R. E. Bourey & J. W. Hill & D. Y. Jung &
D. A. Morgan & J. K. Kim & S. K. Rahmouni & S. M. Najjar
Received: 22 August 2011 /Accepted: 7 November 2011
# Springer-Verlag 2011
Abstract
Aims/hypothesis The carcino-embryonic antigen-related
cell adhesion molecule (CEACAM)2 is produced in many
feeding control centres in the brain, but not in peripheral
insulin-targeted tissues. Global Ceacam2 null mutation
causes insulin resistance and obesity resulting from hyper-
phagia and hypometabolism in female Ceacam2 homozy-
gous null mutant mice (Cc2 [also known as Ceacam2]-/-
)
mice. Because male mice are not obese, the current study
examined their metabolic phenotype.

  

Source: Abraham, Nader G. - Department of Physiology and Pharmacology, University of Toledo

 

Collections: Biology and Medicine