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Cis-Regulatory Elements and Epigenetic Changes Control

Summary: CHAPTER 1
Cis-Regulatory Elements and
Epigenetic Changes Control
Genomic Rearrangements
of the IgH Locus
Thomas Perlot*,
and Frederick W. Alt*
Contents 1. Introduction 2
2. The Immunoglobulin Heavy Chain Locus 3
3. V(D)J Recombination During B-Cell Development 4
4. Class Switch Recombination and
Somatic Hypermutation 7
5. IgH Rearrangements and Allelic Exclusion 8
6. Accessibility Control 10
6.1. Germline transcripts 10
6.2. Spatial organization and nuclear positioning
of the IgH locus 12
6.3. Chromatin modifications 13
7. IgH Locus Control Through Cis-Regulatory Elements 16
7.1. Promoter of DQ52 16


Source: Alt,, Frederick - Immune Disease Institute, Harvard University


Collections: Biology and Medicine