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Molecular Ecology Resources (2009) 9, 11271131 doi: 10.1111/j.1755-0998.2009.02562.x 2009 Blackwell Publishing Ltd
 

Summary: Molecular Ecology Resources (2009) 9, 11271131 doi: 10.1111/j.1755-0998.2009.02562.x
2009 Blackwell Publishing Ltd
Blackwell Publishing Ltd
COMPUTER PROGRAM NOTE
KINALYZER, a computer program for reconstructing
sibling groups
M. V. ASHLEY,* I. C. CABALLERO,* W. CHAOVALITWONGSE, B. DASGUPTA, P. GOVINDAN,
S. I. SHEIKH and T. Y. BERGER-WOLF
*Department of Biological Sciences, M/C 066, University of Illinois at Chicago, 845 W. Taylor Street, Chicago, IL 60607, USA,
Department of Industrial and Systems Engineering, Rutgers University, CoRE Building, 96 Frelinghuysen Road, Piscataway, NJ
08854, USA, Department of Computer Science, M/C 152, University of Illinois at Chicago, 851 S. Morgan, Chicago, IL 60607, USA
Abstract
A software suite KINALYZER reconstructs full-sibling groups without parental informa-
tion using data from codominant marker loci such as microsatellites. KINALYZER utilizes
a new algorithm for sibling reconstruction in diploid organisms based on combinatorial
optimization. KINALYZER makes use of a Minimum 2-Allele Set Cover approach based on
Mendelian inheritance rules and finds the smallest number of sibling groups that contain
all the individuals in the sample. Also available is a `Greedy Consensus' approach that
reconstructs sibgroups using subsets of loci and finds the consensus of the partial solutions.
Unlike likelihood methods for sibling reconstruction, KINALYZER does not require

  

Source: Ashley, Mary V. - Department of Biological Sciences, University of Illinois at Chicago

 

Collections: Biology and Medicine; Environmental Sciences and Ecology