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invited review Modulation of membrane traffic by mechanical stimuli
 

Summary: invited review
Modulation of membrane traffic by mechanical stimuli
GERARD APODACA
Laboratory of Epithelial Cell Biology, Renal-Electrolyte Division,
Department of Medicine, and Department of Cell Biology and Physiology,
University of Pittsburgh, Pittsburgh, Pennsylvania 15261
Apodaca, Gerard. Modulation of membrane traffic by mechanical
stimuli. Am J Physiol Renal Physiol 282: F179F190, 2002.--All cells
experience and respond to mechanical stimuli, such as changes in
plasma membrane tension, shear stress, hydrostatic pressure, and
compression. This review is an examination of the changes in mem-
brane traffic that occur in response to mechanical forces. The plasma
membrane has an associated tension that modulates both exocytosis
and endocytosis. As membrane tension increases, exocytosis is stim-
ulated, which acts to decrease membrane tension. In contrast, in-
creased membrane tension slows endocytosis, whereas decreased ten-
sion stimulates internalization. In most cases, secretion is stimulated
by external mechanical stimuli. However, in some cells mechanical
forces block secretion. External stimuli also enhance membrane and
fluid endocytosis in several cell types. Transduction of mechanical

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collections: Biology and Medicine