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PIER: Protein Interface Recognition for Structural Proteomics

Summary: PIER: Protein Interface Recognition for
Structural Proteomics
Irina Kufareva,1
Levon Budagyan,2
Eugene Raush,2
Maxim Totrov,2
and Ruben Abagyan1,2*
Scripps Research Institute, La Jolla, California 92037
Molsoft LLC, La Jolla, California 92037
ABSTRACT Recent advances in structural
proteomics call for development of fast and reli-
able automatic methods for prediction of func-
tional surfaces of proteins with known three-
dimensional structure, including binding sites for
known and unknown protein partners as well as
oligomerization interfaces. Despite significant pro-
gress the problem is still far from being solved.
Most existing methods rely, at least partially, on ev-


Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego


Collections: Biology and Medicine