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Definition and Evaluation of MRI-Based Measures for the Neuroradiological

Summary: Definition and Evaluation of MRI-Based
Measures for the Neuroradiological
Investigation of Creutzfeld-Jakob Diseases
by Marius George Linguraru and Nicholas Ayache
The identification of diagnosis markers is a major challenge in the clinical care of patients
with Creutzfeldt-Jakob Disease (CJD). A study was carried out as part of the French 'GIS-
Prions' project to detect and quantify CJD-specific abnormal intensities in Magnetic
Resonance Imaging of the brain.
Of great concern has been the occurrence in the United Kingdom in the 1990s of variant CJD (vCJD), a
form of human environmentally acquired CJD, also known as 'mad cow disease'. Although the number of
vCJD cases has decreased since 2001, a new risk exists of transmission by blood transfusion. The disease
raises a number of challenges for neuroradiological centres, since there exists only limited knowledge of
how it might be detected through medical imaging. We have studied the detection and quantification of
CJD-specific abnormal intensities in magnetic resonance imaging (MRI) of the brain in order to diagnose
CJD patients and differentiate vCJD from sporadic CJD (sCJD) cases.
MRI is commonly used for non-invasive examinations of patients with neurological diseases. Some recent
studies have found strong correspondences between the diagnosis of CJD and the detection through MRI of
signal abnormality in the deep grey matter internal nuclei of the brain. However, observations describing
the ability of MRI to assist in the diagnosis of CJD are at an early stage, and the visual interpretation of MR
images performed by physicians can be challenging. At present, MRI is not included as a diagnosis


Source: Ayache, Nicholas - INRIA


Collections: Computer Technologies and Information Sciences; Engineering