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THE JOURNAL OF COMPARATIVE NEUROLOGY 308:467-490 (1991) Anatomic Evidence of Nociceptive Inputs
 

Summary: THE JOURNAL OF COMPARATIVE NEUROLOGY 308:467-490 (1991)
Anatomic Evidence of Nociceptive Inputs
to Primary Somatosensory Cortex:
RelationshipBetween Spinothalamic
Terminals and Thalamocortical Cells
in Squirrel Monkeys
SCOTT I. GINGOLD, JOEL D. GREENSPAN, AND A. VANIA APKARIAK
Department of Neurosurgery, SUNYHealth ScienceCenter at Syracuse,
Syracuse,New York 13210
ABSTRACT
This study examined anatomic pathways that are likely to transmit noxious and thermal
cutaneous information to the primary somatosensory cortex. Anterograde and retrograde
labelingtechniques werecombinedto investigatetherelationship between spinothalamic (STT)
projections and thalamocortical neurons in the squirrel monkey (Saimiri sciureus). Large
injections of diamidino yellow (DY)were placed in the physiologically defined hand region of
primary somatosensory cortex (hSI), and wheat germ agglutinin-horseradish peroxidase
(WGA-HRP)was injected in the contralateral cervical enlargement (C5-TJ. Both DY-labeled
neuronal cell bodies and HRP-labeled STT terminal-like structures were visualized within
singlethalamic sections in each animal. Quantitative analysis of the positions and numbers of
retrogradely labeled neurons and anterogradely labeled terminal fields reveal that: 1)ventral

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine