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Caffeine Effects on Cardiovascular and Neuroendocrine Responses to Acute Psychosocial Stress and Their Relationship to Level of
 

Summary: Caffeine Effects on Cardiovascular and Neuroendocrine Responses
to Acute Psychosocial Stress and Their Relationship to Level of
Habitual Caffeine Consumption
JAMES D. LANE, PH.D., R. ALISON ADCOCK, B.A.,
REDFORD B. WILLIAMS, M.D., AND CYNTHIA M. KUHN, PH.D.
The effects of a moderate dose of caffeine on cardiovascular and neuroendocrine stress
reactivity were examined in 25 healthy male subjects selected as habitual or light consumers
of caffeine. Measurements were taken under resting conditions before and after administration
of caffeine (3 5 mg/kg) or placebo, during a stressful laboratory task, and in a post-stress
recovery period. Caffeine elevated blood pressure and plasma norepinephrine levels at rest,
effects which added significantly to the effects of stress. Caffeine potentiated stress-related
increases in plasma epinephrine and cortisol stress, more than doubling the responses observed
in the control condition. These effects were present in both habitual and light consumers and
level of habitual caffeine consumption did not affect their magnitude. Results indicate that
caffeine can potentiate both cardiovascular and neuroendocrine stress reactivity and that the
habitual use of caffeine is not necessarily associated with the development of tolerance to
these effects.
INTRODUCTION
Caffeine is one of the most widely con-
sumed drugs in the world and is certainly

  

Source: Adcock, R. Alison - Center for Cognitive Neuroscience & Department of Psychological and Brain Sciences, Duke University

 

Collections: Biology and Medicine