The continuing deluge of nucleotide polymorphism data is
providing insights into the role of adaptation in shaping
genome-wide patterns of variability and molecular evolution.
Population genetic models in which linkage and selection
interact (i.e. hitchhiking) predict that selection can leave
`footprints' in closely linked genomic regions. New analytical
approaches show promise for distinguishing the signature of
adaptation from that of several non-adaptive alternatives.
Accounting for the effects of population structure and history
poses a challenge for future investigations.
Institute of Cell, Animal and Population Biology, University of
Edinburgh, Ashworth Labs, King's Buildings, Edinburgh, EH9 3JT, UK;
Current Opinion in Genetics & Development 2001, 11:635641
0959-437X/01/$ -- see front matter
© 2001 Elsevier Science Ltd. All rights reserved.
Most nucleotide variability observed in natural populations