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The continuing deluge of nucleotide polymorphism data is providing insights into the role of adaptation in shaping
 

Summary: 635
The continuing deluge of nucleotide polymorphism data is
providing insights into the role of adaptation in shaping
genome-wide patterns of variability and molecular evolution.
Population genetic models in which linkage and selection
interact (i.e. hitchhiking) predict that selection can leave
`footprints' in closely linked genomic regions. New analytical
approaches show promise for distinguishing the signature of
adaptation from that of several non-adaptive alternatives.
Accounting for the effects of population structure and history
poses a challenge for future investigations.
Addresses
Institute of Cell, Animal and Population Biology, University of
Edinburgh, Ashworth Labs, King's Buildings, Edinburgh, EH9 3JT, UK;
e-mail: Peter.Andolfatto@ed.ac.uk
Current Opinion in Genetics & Development 2001, 11:635641
0959-437X/01/$ -- see front matter
2001 Elsevier Science Ltd. All rights reserved.
Introduction
Most nucleotide variability observed in natural populations

  

Source: Andolfatto, Peter - Department of Ecology and Evolutionary Biology, Princeton University

 

Collections: Biology and Medicine