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Summary: Complementary targeting of liposomes to IL-1a and TNF-a activated endothelial
cells via the transient expression of VCAM1 and E-selectin
Rico C. Gunawan, Dariela Almeda, Debra T. Auguste*
School of Engineering and Applied Sciences, Harvard University, 29 Oxford St., Cambridge, MA 02138, USA
a r t i c l e i n f o
Article history:
Received 19 August 2011
Accepted 31 August 2011
Available online 22 September 2011
Keywords:
Liposome
Inflammation
Endothelial cell
E-selectin
VCAM1
Transient
a b s t r a c t
Inflammation is in part defined by the transient upregulation of cell adhesion molecules on the surface of
endothelial cells (ECs) in response to cytokines. We hypothesized that liposomes with a complementary
surface presentation of antibodies to the pattern of molecules on the EC surface may enhance targeting.
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