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Neuron, Vol. 38, 857862, June 19, 2003, Copyright 2003 by Cell Press ReportSpecificity of G Protein-RGS
 

Summary: Neuron, Vol. 38, 857862, June 19, 2003, Copyright 2003 by Cell Press
ReportSpecificity of G Protein-RGS
Protein Recognition
Is Regulated by Affinity Adapters
rods and cones (see Burns and Baylor, 2001; Arshavsky
et al., 2002, for recent reviews). In this cascade, pho-
toexcited rhodopsin activates G protein transducin
(G t), which then stimulates the activity of the effector
enzyme, cGMP phosphodiesterase (PDE), by binding to
Kirill A. Martemyanov, Johnathan A. Hopp,
and Vadim Y. Arshavsky*
Howe Laboratory of Ophthalmology
Harvard Medical School
The Massachusetts Eye and Ear Infirmary
Boston, Massachusetts 02114 the PDE -subunit and releasing the inhibitory constraint
that PDE imposes on the PDE catalytic subunits. The
lifetime of the activated G t in this pathway is regulated
by the short splice isoform of RGS9, RGS9-1 (He et al.,Summary
1998; Chen et al., 2000). Critical to this regulation is the
ability of RGS9-1 to interact selectively with G t boundRGS proteins regulate the duration of cell signaling by

  

Source: Arshavsky, Vadim Y. - Department of Pharmacology, Duke University

 

Collections: Biology and Medicine