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Hostile Takeover by Plasmodium: Reorganization of Parasite and Host Cell Membranes during Liver Stage
 

Summary: Hostile Takeover by Plasmodium: Reorganization of
Parasite and Host Cell Membranes during Liver Stage
Egress
Stefanie Graewe1
*, Kathleen E. Rankin1
, Christine Lehmann1
, Christina Deschermeier1
, Leonie Hecht1
,
Ulrike Froehlke1
, Rebecca R. Stanway2
, Volker Heussler2
1 Malaria Lab I, Department of Molecular Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, 2 Institute of Cell Biology, University of Bern,
Bern, Switzerland
Abstract
The protozoan parasite Plasmodium is transmitted by female Anopheles mosquitoes and undergoes obligatory development
within a parasitophorous vacuole in hepatocytes before it is released into the bloodstream. The transition to the blood
stage was previously shown to involve the packaging of exoerythrocytic merozoites into membrane-surrounded vesicles,
called merosomes, which are delivered directly into liver sinusoids. However, it was unclear whether the membrane of these
merosomes was derived from the parasite membrane, the parasitophorous vacuole membrane or the host cell membrane.

  

Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia

 

Collections: Biotechnology