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Secretin Occupies a Single Protomer of the Homodimeric Secretin Receptor Complex
 

Summary: Secretin Occupies a Single Protomer of the Homodimeric
Secretin Receptor Complex
INSIGHTS FROM PHOTOAFFINITY LABELING STUDIES USING DUAL SITES OF COVALENT
ATTACHMENT*
Received for publication,November 27, 2009, and in revised form, January 11, 2010 Published, JBC Papers in Press,January 25, 2010, DOI 10.1074/jbc.M109.089730
Maoqing Dong
, Polo C.-H. Lam§¶
, Delia I. Pinon
, Andrew Orry§¶
, Patrick M. Sexton , Ruben Abagyan§¶
,
and Laurence J. Miller1
From the
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona 85259, the
§
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92037, ¶
Molsoft
LLC, La Jolla, California 92037, and the Drug Discovery Biology Laboratory, Monash Institute of Pharmaceutical Sciences, and
Department of Pharmacology, Monash University, Parkville 3052, Australia
The secretin receptor, a prototypic family B G protein-cou-

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collections: Biology and Medicine