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Helminth regulation of host IL-4R Stat6 signaling: Mechanism underlying NOS-2 inhibition by
 

Summary: Helminth regulation of host IL-4R Stat6 signaling:
Mechanism underlying NOS-2 inhibition by
Trichinella spiralis
Ka Bian, Meng Zhong, Yael Harari, Mildred Lai, Norman Weisbrodt, and Ferid Murad*
Department of Integrative Biology and Pharmacology, Institute of Molecular Medicine, University of Texas Medical School, 6431 Fannin,
Houston, TX 77030
Contributed by Ferid Murad, December 31, 2004
Gastrointestinal nematode infection is known to alter host T cell
activation and has been used to study immune and inflammatory
reactions in which nitric oxide (NO) is a versatile player. We
previously demonstrated that Trichinella spiralis infection inhibits
host inducible NO synthase (NOS-2) expression. We now demon-
strate that (i) an IL-4 receptor -subunit (IL-4R ) Stat6-dependent
but T cell-independent pathway is the key for the nematode-
induced host NOS-2 inhibition; (ii) endogenous IL-4 and IL-13, the
only known IL- 4R ligands, are not required for activating the
pathway; and (iii) treatment of RAW264.7 cells with parasite-
cultured medium inhibits NOS-2 expression but not cyclooxygen-
ase 2 expression. We propose that a yet-unidentified substance is
released by the nematode during the host­parasite interaction.

  

Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia

 

Collections: Biotechnology