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Summary: Written by Mirella Bucci, Amy Donner,
Catherine Goodman & Joanne Kotz
Stereochemistry-
independent sterols
Oxygenated derivatives of cholesterol, or
oxysterols, regulate cholesterol homeostasis
by interacting directly with Insig proteins
and promoting both endoplasmic reticulum
(ER) retention of transcription factors that
control expression of cholesterol synthesis
genes and degradation of the cholesterol
biosynthetic enzyme HMG CoA reductase
(HMGR). Gale et al. used the side chain oxy
sterol 25hydroxycholesterol (HC) and its
enantiomer, ent25HC, to demonstrate that
sterol regulatory element (SRE)dependent
transcription and HMGR degradation
occur independently of HC stereochemistry.
Because steroidprotein interactions are ex
pected to be enantiospecific, these data are
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