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Fatty Acid Synthesis by Elongases in Trypanosomes
 

Summary: Fatty Acid Synthesis by
Elongases in Trypanosomes
Soo Hee Lee,1
Jennifer L. Stephens,1
Kimberly S. Paul,1,2
and Paul T. Englund1,
*
1
Department of Biological Chemistry, Johns Hopkins Medical School, Baltimore, MD 21205, USA
2
Present address: Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA.
*Contact: penglund@jhmi.edu
DOI 10.1016/j.cell.2006.06.045
SUMMARY
All eukaryotic and prokaryotic organisms are
thought to synthesize fatty acids using a type I
or type II synthase. In addition, eukaryotes ex-
tend pre-existing long chain fatty acids using
microsomal elongases (ELOs). We have found
that Trypanosoma brucei, a eukaryotic human

  

Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia

 

Collections: Biotechnology