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ORIGINAL INVESTIGATION Memory and psychostimulants: modulation of Pavlovian

Memory and psychostimulants: modulation of Pavlovian
fear conditioning by amphetamine in C57BL/6 mice
Suzanne C. Wood & Stephan G. Anagnostaras
Received: 15 April 2007 /Accepted: 22 April 2008 / Published online: 15 May 2008
# Springer-Verlag 2008
Rationale and objectives With the use of prescription
stimulants on the rise, it is important to examine the
cognitive effects of low and moderate doses of stimulants
rather than only those typical of addicts.
Materials and methods The present study examined the
effects a range of doses (0.0058 mg/kg) of D-amphetamine
sulfate on cued and contextual Pavlovian fear conditioning
in mice.
Results In agreement with previous research, subjects
administered with a moderately high dose of amphetamine
(8 mg/kg) pre-training, typical of what addicts might take,
displayed impaired conditioned freezing when tested off-
drug. Alternately, subjects injected with a very low dose of


Source: Anagnostaras, Stephan - Neurosciences Program & Department of Psychology, University of California at San Diego


Collections: Biology and Medicine