Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Copyright 2000 by the Genetics Society of America A Genome-Wide Departure From the Standard Neutral Model
 

Summary: Copyright 2000 by the Genetics Society of America
A Genome-Wide Departure From the Standard Neutral Model
in Natural Populations of Drosophila
Peter Andolfatto*,1
and Molly Przeworski,1
*Institute for Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom and

Committee on Evolutionary Biology, University of Chicago, Chicago, Illinois 60637
Manuscript received July 24, 1999
Accepted for publication May 25, 2000
ABSTRACT
We analyze nucleotide polymorphism data for a large number of loci in areas of normal to high
recombination in Drosophila melanogaster and D. simulans (24 and 16 loci, respectively). We find a genome-
wide, systematic departure from the neutral expectation for a panmictic population at equilibrium in
natural populations of both species. The distribution of sequence-based estimates of 2Nc across loci is
inconsistent with the assumptions of the standard neutral theory, given the observed levels of nucleotide
diversity and accepted values for recombination and mutation rates. Under these assumptions, most
estimates of 2Nc are severalfold too low; in other words, both species exhibit greater intralocus linkage
disequilibrium than expected. Variation in recombination or mutation rates is not sufficient to account
for the excess of linkage disequilibrium. While an equilibrium island model does not seem to account

  

Source: Andolfatto, Peter - Department of Ecology and Evolutionary Biology, Princeton University

 

Collections: Biology and Medicine