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SYNAPTIC AND SUBCELLULAR LOCALIZATION OF A-KINASE ANCHORING PROTEIN 150 IN RAT HIPPOCAMPAL CA1 PYRAMIDAL
 

Summary: SYNAPTIC AND SUBCELLULAR LOCALIZATION OF A-KINASE
ANCHORING PROTEIN 150 IN RAT HIPPOCAMPAL CA1 PYRAMIDAL
CELLS: CO-LOCALIZATION WITH EXCITATORY SYNAPTIC MARKERS
S. M. LILLY,a
F. J. ALVAREZb1
AND E. I. TIETZa1
*
a
Department of Pharmacology and the Cellular and Molecular Neuro-
biology Program, 3035 Arlington Avenue, Medical University of Ohio,
Toledo, OH 43614, USA
b
Department of Anatomy and Physiology, 3640 Colonel Glenn High-
way, Wright State University, Dayton, OH 45435, USA
Abstract--Excitatory and inhibitory ionotropic receptors are
regulated by protein kinases and phosphatases, which are
localized to specific subcellular locations by one of several
anchoring proteins. One of these is the A-kinase anchoring
protein (AKAP150), which confers spatial specificity to pro-
tein kinase A and protein phosphatase 2B in the rat brain. The

  

Source: Alvarez, Francisco J. - Department of Neuroscience, Cell Biology, and Physiology, Wright State University
Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collections: Biology and Medicine