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Inflammatory Monocytes Are Required for Mucosal Resistance to the Pathogen
 

Summary: Immunity
Article
Gr1+
Inflammatory Monocytes Are Required
for Mucosal Resistance to the Pathogen
Toxoplasma gondii
Ildiko R. Dunay,1,5 Renato A. DaMatta,1,4,5 Blima Fux,1 Rachel Presti,2 Suellen Greco,3 Marco Colonna,2
and L. David Sibley1,*
1Department of Molecular Microbiology
2Department of Pathology
3Division of Comparative Medicine
Washington University School of Medicine, St. Louis, MO 63110, USA
4Present Address: LBCT, CBB, UENF, Campos dos Goytacazes, RJ 28013-602, Brazil
5These authors contributed equally to this work
*Correspondence: sibley@wustl.edu
DOI 10.1016/j.immuni.2008.05.019
SUMMARY
The enteric pathogen Toxoplasma gondii is con-
trolled by a vigorous innate T helper 1 (Th1) cell re-
sponse in the murine model. We demonstrated that

  

Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia

 

Collections: Biotechnology