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Long-term testretest reliability of functional MRI in a classification learning task

Summary: Long-term test­retest reliability of functional MRI in a classification
learning task
Adam R. Aron, Mark A. Gluck, and Russell A. Poldrack*
Department of Psychology, Franz Hall Box 951563, University of California, Los Angeles, CA 90095, USA
Received 9 June 2005; revised 29 July 2005; accepted 4 August 2005
Available online 1 September 2005
Functional MRI is widely used for imaging the neural correlates of
psychological processes and how these brain processes change with
learning, development and neuropsychiatric disorder. In order to
interpret changes in imaging signals over time, for example, in patient
studies, the long-term reliability of fMRI must first be established.
Here, eight healthy adult subjects were scanned on two sessions, 1 year
apart, while performing a classification learning task known to activate
frontostriatal circuitry. We show that behavioral performance and
frontostriatal activation were highly concordant at a group level at
both time-points. Furthermore, intra-class correlation coefficients
(ICCs), which index the degree of correlation between subjects at
different time-points, were high for behavior and for functional
activation. ICC was significantly higher within the network recruited
by learning than outside that network. We conclude that fMRI can


Source: Aron, Adam - Department of Psychology, University of California at San Diego
Gluck, Mark - Center for Molecular and Behavioral Neuroscience, Rutgers University at Newark
Poldrack, Russ - Department of Psychology & Section of Neurobiology, Division of Biological Sciences, University of Texas at Austin


Collections: Biology and Medicine; Computer Technologies and Information Sciences