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SHORT REVIEW The quest for natural selection in the age of

The quest for natural selection in the age of
comparative genomics
M Anisimova1
and DA Liberles2
Department of Biology, University College London, London, UK and 2
Department of Molecular Biology, University of Wyoming,
Laramie, WY, USA
Continued genome sequencing has fueled progress in
statistical methods for understanding the action of natural
selection at the molecular level. This article reviews various
statistical techniques (and their applicability) for detecting
adaptation events and the functional divergence of proteins.
As large-scale automated studies become more frequent,
they provide a useful resource for generating biological null
hypotheses for further experimental and statistical testing.
Furthermore, they shed light on typical patterns of lineage-
specific evolution of organisms, on the functional and
structural evolution of protein families and on the interplay


Source: Anisimova, Maria - Institute of Scientific Computing, Eidgenössische Technische Hochschule Zürich (ETHZ)


Collections: Biology and Medicine