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THEJOURNALOF BI~L~GICALCHEMISTRY 0 1994 by The American Society for Biochemistry and Molecular Biology, Inc
 

Summary: THEJOURNALOF BI~L~GICALCHEMISTRY
0 1994 by The American Society for Biochemistry and Molecular Biology, Inc
Vol. 269, No. 35, Issue of September 2, pp. 22358-22365, 1994
Printed in U.S.A.
Human Apo~i~o~rot~inE
ROLE OF ~ G I N ~ E61 IN ~ E D ~ T I N GTHE L ~ P O P R O T E ~ P R E F ~ R ~ N C E SOF THE E3 AND E4 I S O F O ~ S *
(Received forpublication,April 12, 1994, and in revised form,June 15, 1994)
Li-MingDon&, Charles Wilsonžn,Mark R. WardellSII, Trey Simmons+,Robert W. MahleyS $+SO,
Karl H.WeisgraberS $$ m, and David A. Agardo
From the $Gladstone Institute ofCardiovascular Disease, Cardiovascular Research Institute, the Departmentsof
$$Pathology and @Medicine, University of California, San Francisco, California 94141-9100,the $Howard Hughes
Medical Institute. Graduate Groua in Bioahvsics. Deaartment of Biochemistry and Biophysics, University of California,
San Francisco, California 94143-0448
- I , -
Human apolipoprotein (apo) E4 (arginine at residue
112)preferentially associates with very low density li-
poproteins (VLDL), and apoE3 (cysteine at 112)associ-
ates with high density lipoproteins. It hasbeen postu-
lated that the amino-terminal domain, which contains
residue 112,influencesthe lipoprotein preference by in-

  

Source: Agard, David - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collections: Biotechnology; Biology and Medicine