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Summary: Transgene-Mediated RNA Interference Defines a Novel
Role for Notch in Chemosensory Startle Behavior
Asaf Presente,1
Susan Shaw,1
Jeffrey S. Nye,2
and Andrew J. Andres3
*
1
Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, Illinois
2
CNS Genomics Discovery Research, Pharmacia Corporation, Kalamazoo, Michigan
3
Department of Biological Sciences, University of Nevada-Las Vegas, Las Vegas, Nevada
Received 2 July 2002; Accepted 19 July 2002
The Notch signal transduction system functions in the
developmental differentiation of a wide variety of tissues
in every metazoan thus far examined (Artavanis-Tsako-
nas et al., 1999). In addition, recent evidence has shown
that Notch function is important even after cell fate
decisions are made. Examples include control of neurite
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