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INTRODUCTION The mesodermal germ layer contributes cells to the notochord,

The mesodermal germ layer contributes cells to the notochord,
musculature, kidney and blood and organises the development
of the dorsal to ventral and anterior to posterior axes of the
body (Harland and Gerhart, 1997). In Xenopus, mesoderm is
induced around the equator of the embryo at the blastula stages
by signals emanating from the vegetal pole. Following this,
during the gastrula stages, antagonistic interactions between a
second set of signals that arise from the dorsal and ventral
domains pattern the mesoderm along its dorsoventral axis.
Several signal transduction pathways that function during
mesoderm induction and patterning have been identified (for
reviews, see Chan and Etkin, 2001; Dale and Jones, 1999;
Heasman, 1997). However, we lack a full understanding of how
these pathways integrate to pattern the mesoderm. In particular,
little is known about how the mesoderm is patterned into its
four major compartments, representing the notochord, somites,
pronephros and blood.
Xmyf-5 encodes a basic helix-loop-helix (bHLH)
transcription factor related to MyoD, myogenin and MRF4, all


Source: Amaya, Enrique - Healing Foundation Centre & Developmental Biology, Faculty of Life Sciences, University of Manchester


Collections: Biology and Medicine