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Effects of angiotensin II and C-type natriuretic peptide on the in situ perfused trunk preparation of the dogfish,
 

Summary: Effects of angiotensin II and C-type natriuretic peptide
on the in situ perfused trunk preparation of the dogfish,
Scyliorhinus canicula
Alan Wells a,*, W. Gary Anderson b
, Jenna E. Cains a
, Martin W. Cooper a
, Neil Hazon a
a
School of Biology, Gatty Marine Laboratory, University of St Andrews, St Andrews, Fife KY16 8LB, Scotland, UK
b
Department of Zoology, Duff Roblin Building, University of Manitoba, Winnipeg, MB, Canada R3T 2N2
Received 13 January 2005; revised 3 August 2005; accepted 5 August 2005
Available online 26 September 2005
Abstract
The renal roles of physiologically relevant doses of angiotensin II (Ang II) and C-type natriuretic peptide (CNP) were investigated in
the dogfish, Scyliorhinus canicula, using an in situ perfused trunk preparation. Perfusion with 109
M Ang II resulted in a glomerular
antidiuresis and decreases in perfusate flow rate, transport maxima for glucose and the proportion of filtering glomeruli. In addition,
the renal clearances and excretion of urea, sodium, and chloride were significantly reduced, whereas the relative clearances of these
parameters remained unchanged. In contrast, perfusion of 109

  

Source: Anderson, W. Gary - Department of Biological Sciences, University of Manitoba

 

Collections: Biology and Medicine