Summary: A Potential Dubin­Johnson Syndrome Imaging Agent:
Synthesis, Biodistribution, and MicroPET Imaging
Jeongsoo Yoo, David E. Reichert, Joonyoung Kim, Carolyn J. Anderson, and Michael J. Welch
Washington University School of Medicine
Abstract
Dubin­Johnson syndrome (DJS) is caused by a deficiency of
the human canalicular multispecific organic anion transporter
(cMOAT). A new lipophilic copper-64 complex of 1,4,7-
tris(carboxymethyl)-10-(tetradecyl)-1,4,7,10-tetraazadodecane
(5) was prepared and evaluated for potential as a diagnostic
tool for DJS. The prepared ligand was labeled with 64
Cu citrate
in high radiochemical purity. In vivo uptake and clearance of
the complex was determined through biodistribution studies
using normal Sprague­Dawley rats and mutant cMOAT-defi-
cient (TRÀ
) rats. In normal rats, the radioactive copper com-
plex was cleared quickly from the body exclusively through
the hepatic pathway. The 64
Cu complex was taken up rapidly

Source: Anderson, Carolyn J. - Department of Molecular Biology and Pharmacology, Washington University in St. Louis

Collections: Biology and Medicine