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ARTICLE Communicatedby JohnRime1 Analysis of Neuron Models with

Summary: ARTICLE Communicatedby JohnRime1
Analysis of Neuron Models with
Dynamically Regulated Conductances
L.F. Abbott*
Gwendal LeMassont
Departmentsof Physics' and Biologyt, and Centerfor ComplexSystems,
Brandeis University, Waltham,MA 02254 USA
We analyze neuron models in which the maximal conductances of
membrane currents are slowly varying dynamic variables regulated by
the intracellular calcium concentration. These models allow us to study
possible activity-dependent effects arising from processes that main-
tain and modify membrane channels in real neurons. Regulated model
neurons maintain a constant averagelevel of activity over a wide range
of conditions by appropriately adjusting their conductances. The in-
tracellular calcium concentration acts as a feedback element linking
maximal conductances to electrical activity. The resulting plasticity of
intrinsic characteristicshas important implications for network behav-
ior. We first study a simple two-conductance model, then introduce
techniques that allow us to analyze dynamic regulation with an ar-
bitrary number of conductances, and finally illustrate this method by


Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University


Collections: Biology and Medicine