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Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors,
 

Summary: Cellular adaptation to hypoxia: O2-sensing protein
hydroxylases, hypoxia-inducible transcription factors,
and O2-regulated gene expression
ROLAND H. WENGER
Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
ABSTRACT Although it was known for a long time
that oxygen deprivation leads to the transcriptional
induction of the gene encoding erythropoietin, the
molecular mechanisms behind this process remained
enigmatic. The cloning of the hypoxia-inducible fac-
tors (HIFs), the finding that HIF-1 regulates the
expression of many more genes apart from erythro-
poietin, and the elucidation of the oxygen-depen-
dent mechanisms degrading the HIF subunits
recently led to the spectacular discovery of the
molecular principles of oxygen sensing. This review
aims to summarize our current knowledge of oxygen-
regulated gene expression.--Wenger, R. H. Cellular
adaptation to hypoxia: O2-sensing protein hydroxy-
lases, hypoxia-inducible transcription factors, and

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collections: Biology and Medicine