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Cell, Vol. 86, 619629, August 23, 1996, Copyright 1996 by Cell Press G Proteins Are Required for Spatial Orientation
 

Summary: Cell, Vol. 86, 619629, August 23, 1996, Copyright 1996 by Cell Press
G Proteins Are Required for Spatial Orientation
of Early Cell Cleavages in C. elegans Embryos
Richard R. Zwaal,1, 5, 7
Julie Ahringer,2, 3, 7
that change the levels of second messengers inside the
cell (for reviews see Gilman, 1987; Birnbaumer, 1992;Henri G. A. M. van Luenen,1
Alice Rushforth,4, 6
Phil Anderson,4
and Ronald H. A. Plasterk1
Clapham and Neer, 1993; Neer, 1995).
To study the function of G proteins in vivo, and to1
The Netherlands Cancer Institute
Division of Molecular Biology identify other elements acting in the signaling cascade,
we have begun to explore G proteins in the nematodePlesmanlaan 121
1066 CX Amsterdam Caenorhabditis elegans. At present, nine subunits
have been identified in C. elegans, including membersThe Netherlands
2
University of Cambridge of the conserved families G o (Lochrie et al., 1991), G s
(J.-H. Park et al., unpublished data), G q (Brundage etDepartment of Genetics

  

Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge

 

Collections: Biology and Medicine