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NEST Scientific Report 2007-2009 Nanotechnology for intracellular delivery and targeting of drugs, nanoreporters
 

Summary: NEST Scientific Report 2007-2009
Nanotechnology for intracellular delivery and targeting of drugs, nanoreporters
and nanoactuators
95
T
he selective permeability of the plasma membrane prohibits most exogenous
agents from gaining cellular access. A very effective class of transporters for the
internalization of drugs, biosensors and imaging agents are cell penetrating peptides
(CPPs), a group of short cationic sequences with a remarkable capacity for membrane
translocation. Cell-penetrating peptides guarantee high delivery yield, low toxicity and
the possibility to enter a wide range of target cells. Moreover they can act as molecular
carriers for delivery of cargoes (e.g. proteins and nucleic acids) to relevant sub-cellular
domains (mitochondria, endosomal vesicles and nucleus). This report describes recent
advances in the use of Tat arginin-rich peptides and provides further information on the
controversial mechanism of its nuclear entry. Nuclear localization is particularly significant,
as it is one of the fundamental steps for gene-therapy approaches and can open the way
to probe and modify cellular processes of utmost importance.
Peptide-mediated delivery of bioactive
molecules appears to be a new
biotechnology tool that in many aspects

  

Source: Abbondandolo, Alberto - Scuola Normale Superiore of Pisa

 

Collections: Mathematics