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The Journal of Neuroscience, July 1994, 14(7): 4467-4460 Locus Coeruleus Neurons in Monkey Are Selectively Activated by
 

Summary: The Journal of Neuroscience, July 1994, 14(7): 4467-4460
Locus Coeruleus Neurons in Monkey Are Selectively Activated by
Attended Cues in a Vigilance Task
Gary Aston-Jones,' Janusz Rajkowski,' Piotr Kubiak,' and Tatiana Alexinsky*
`Division of Behavioral Neurobiology, Department of Mental Health Sciences, Hahnemann University, Philadelphia,
Pennsylvania 19102 and *Institute des Neurosciences, CNRS, Universite P & M Curie, Paris 75005, France
Impulse activity was recorded extracellularly from norad-
renergic neurons in the nucleus locus coeruleus (LC; 47 sin-
gle-cell and 126 multicell recordings) of four cynomolgus
monkeys performing an oddball visual discrimination task.
For juice reward, the subjects were required to release a
lever rapidly in response to an infrequent (1 O-20% of trials)
target cue (CS+) that was randomly intermixed with non-
target (CS-) stimuli presented on a video display. All LC
neurons examined were phasically and selectively activated
by target cues in this task. Other task events elicited no
consistent response from these neurons (juice reward, lever
release, fix-spot stimuli, nontarget stimuli). In one animal,
nontarget cues phasically inhibited LC neurons. Pha,sic LC
excitatory responses to target cues in this task occurred at

  

Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina

 

Collections: Biology and Medicine