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Summary: Cell, Vol. 113, 853865, June 27, 2003, Copyright 2003 by Cell Press
Anteroposterior Patterning in Hemichordates
and the Origins of the Chordate Nervous System
ical homologies among these phyla has been fraught
with difficulties, as their adult body plans appear so
divergent (Gee, 1996). Yet, underlying the development
Christopher J. Lowe,1,2,
* Mike Wu,1
Adrian Salic,2
Louise Evans,2
Eric Lander,3
Nicole Stange-Thomann,3
of morphology are distinct gene networks that are ex-Christian E. Gruber,4
John Gerhart,1,
*
pressed at specific locations within the bodies of alland Marc Kirschner2
members of the chordate phylum. A comparison of such1
Department of Molecular and Cell Biology
domains among the three extant deuterostome phylaUniversity of California, Berkeley
could reveal similarities in axial organization obscuredBerkeley, California 94720
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