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Mini-Review: Mapping immune response profiles

Summary: Mini-Review:
Mapping immune response profiles:
The emerging scenario from helminth immunology
Alvaro Díaz1
and Judith E. Allen2
Cµtedra de Inmunología, Departamento de Biociencias, Facultad de Química,
Universidad de la Repfflblica, Montevideo, Uruguay
Institutes of Evolution, Immunology and Infection Research, University of Edinburgh,
Edinburgh, UK
Metazoan parasites of mammals (helminths) belong to highly divergent animal groups
and yet induce a stereotypical host response: Th2-type immunity. It has long been
debated whether this response benefits the host or the parasite. We review the current
literature and suggest that Th2 immunity is an evolutionarily appropriate response to
metazoan invaders both in terms of controlling parasites and repairing the damage they
inflict. However, successful parasites induce regulatory responses, which become
superimposed with, and control, Th2 responses. Beyond helminth infection, this
superimposition of response profiles may be the norm: both Th1 and Th2 responses
coexist with regulatory responses or, on the contrary, with the inflammatory Th17


Source: Allen, Judith - School of Biological Sciences, University of Edinburgh


Collections: Biology and Medicine