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Endotoxin Inhibits Intestinal Epithelial Restitution through Activation of Rho-GTPase and Increased Focal Adhesions*
 

Summary: Endotoxin Inhibits Intestinal Epithelial Restitution through
Activation of Rho-GTPase and Increased Focal Adhesions*
Received for publication, December 12, 2003, and in revised form, March 5, 2004
Published, JBC Papers in Press, March 30, 2004, DOI 10.1074/jbc.M313620200
Selma Cetin, Henri R. Ford§, Laura R. Sysko¶ , Charu Agarwal**, James Wang**,
Matthew D. Neal, Catherine Baty¶ , Gerard Apodaca §§, and David J. Hackam ¶¶
From the Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh and University of
Pittsburgh, Pittsburgh, Pennsylvania 15213 and the ¶Center of Biologic Imaging, the Department of Cell Biology and
Physiology, the **Department of Orthopedic Surgery, Department of Surgery, and the Department of Medicine,
University of Pittsburgh, Pittsburgh, Pennsylvania 15213
Diseases of gut inflammation such as neonatal necro-
tizing enterocolitis (NEC) result after an injury to the
mucosal lining of the intestine, leading to translocation
of bacteria and endotoxin (lipopolysaccharide). Intesti-
nal mucosal defects are repaired by the process of intes-
tinal restitution, during which enterocytes migrate
from healthy areas to sites of injury. In an animal model
of NEC, we determined that intestinal restitution was
significantly impaired compared with control animals.
We therefore sought to determine the mechanisms gov-

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collections: Biology and Medicine