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to eating high-caloric foods that can promote obesity. The findings bode well for a strategy of
 

Summary: to eating high-caloric foods that can promote
obesity. The findings bode well for a strategy of
treating drug abuse and overeating with medi-
cations that inhibit orexin signaling.
WORKING HARDER FOR COCAINE
Dr. Stephanie Borgland of the University of
British Columbia (UBC), Dr. Antonello Bonci
of the University of California, San Francisco
(UCSF), and colleagues demonstrated that
orexin sustains cocaine seeking when access
to the drug becomes difficult. Their findings
suggest that orexin raises the likelihood that a
person who has started using cocaine will con-
tinue--and possibly become addicted--despite
mountingfinancialandsocialcostsofobtaining
and using the drug.
The UBC­UCSF team conducted progres-
sive ratio trials to investigate whether rats with
normal orexin signaling will persist in cocaine
seeking after rats with blocked signaling give

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine