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2 -NH2-MPTP [1-Methyl-4-(2 -aminophenyl)-1,2,3,6-tetrahydropyridine] Depletes Serotonin and Norepinephrine
 

Summary: 2 -NH2-MPTP [1-Methyl-4-(2 -aminophenyl)-1,2,3,6-
tetrahydropyridine] Depletes Serotonin and Norepinephrine
in Rats: A Comparison with 2 -CH3-MPTP [1-Methyl-4-(2 -
methylphenyl)-1,2,3,6-tetrahydropyridine]
ERICA L. UNGER, PASCALE MAZZOLA-POMIETTO, DENNIS L. MURPHY, and ANNE M. ANDREWS
Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania (E.L.U., A.M.A.); Institut National de la SanteŽ et de la Recherche
MeŽdicale, Marseilles, France (P.M.-P.); and Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland (D.L.M.)
Received April 17, 2002; accepted June 20, 2002
ABSTRACT
The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) analog,
1-methyl-4-(2 -aminophenyl)-1,2,3,6-tetrahydropyridine (2 -NH2-
MPTP), depletes brain serotonin and norepinephrine in mice with-
out affecting striatal dopamine. The present study was conducted
to determine whether 2 -NH2-MPTP would be similarly neurotoxic
to rats. Four injections of 20 mg/kg 2 -NH2-MPTP caused 80 to
90% depletions in serotonin and norepinephrine in frontal cortex
and hippocampus in rats 1 week post-treatment. A lower dose of
2 -NH2-MPTP (4 15 mg/kg) also produced large decrements in
serotonin and norepinephrine levels and in serotonin transporter
density measured 3 weeks after neurotoxin administration. Fur-

  

Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University

 

Collections: Biology and Medicine