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Transmembrane Segment 11 Appears to Line the Purine Permeation Pathway of the Plasmodium falciparum
 

Summary: Transmembrane Segment 11 Appears to Line the Purine
Permeation Pathway of the Plasmodium falciparum
Equilibrative Nucleoside Transporter 1 (PfENT1)*
Received for publication,February 18, 2010, and in revised form, March 15, 2010 Published, JBC Papers in Press,March 24, 2010, DOI 10.1074/jbc.M110.115758
Paul M. Riegelhaupt1
, I. J. Frame1
, and Myles H. Akabas§¶2
From the Departments of
Physiology and Biophysics, §
Neuroscience, and ¶
Medicine, Albert Einstein College of Medicine of Yeshiva
University, Bronx, New York 10461
Purine transport is essential for malaria parasites to grow
because they lack the enzymes necessary for de novo purine bio-
synthesis. The Plasmodium falciparum Equilibrative Nucleo-
side Transporter 1 (PfENT1) is a member of the equilibrative
nucleoside transporter (ENT) gene family. PfENT1 is a primary
purine transport pathway across the P. falciparum plasma
membrane because PfENT1 knock-out parasites are not viable
at physiologic extracellular purine concentrations. Topology

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collections: Biology and Medicine