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Genome Biology 2007, 8:R29 commentreviewsreportsdepositedresearchrefereedresearchinteractionsinformation

Summary: Genome Biology 2007, 8:R29
Open Access2007Lev-Maoret al.Volume 8, Issue 2, Article R29Research
RNA-editing-mediated exon evolution
Galit Lev-Maor¤*, Rotem Sorek¤*, Erez Y Levanon§, Nurit Paz¶,
Eli Eisenberg„ and Gil Ast*
Addresses: *Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978,
Israel. Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Compugen Ltd, Pinchas Rosen St, Tel-Aviv
69512, Israel. §Department of Genetics, Harvard Medical School, Avenue Louis Pasteur, Boston, Massachusetts 02115, USA. ¶Department of
Pediatric Hemato-Oncology, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel. „School
of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Ramat Aviv 69978, Israel.
¤ These authors contributed equally to this work.
Correspondence: Gil Ast. Email: gilast@post.tau.ac.il
© 2007 Lev-Maor et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which
permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
RNA-editing-mediated exon evolution

A primate-specific exon is found to be dependent on RNA editing for its exonization.

Background: Alu retroelements are specific to primates and abundant in the human genome.
Through mutations that create functional splice sites within intronic Alus, these elements can


Source: Ast, Gil - Department of Molecular Genetics and Biochemistry, Tel Aviv University
Sorek, Rotem - Department of Molecular Genetics, Weizmann Institute of Science


Collections: Biology and Medicine