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INFECTION AND IMMUNITY, Dec. 2005, p. 79968001 Vol. 73, No. 12 0019-9567/05/$08.00 0 doi:10.1128/IAI.73.12.79968001.2005
 

Summary: INFECTION AND IMMUNITY, Dec. 2005, p. 79968001 Vol. 73, No. 12
0019-9567/05/$08.00 0 doi:10.1128/IAI.73.12.79968001.2005
Copyright 2005, American Society for Microbiology. All Rights Reserved.
Chronic Leishmania donovani Infection Promotes Bystander
CD8 -T-Cell Expansion and Heterologous Immunity
Rosalind Polley, Stephanie L. Sanos, Sara Prickett, Ashraful Haque,
and Paul M. Kaye*
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine,
London WC1E 7HT, United Kingdom
Received 22 July 2005/Accepted 22 August 2005
It has been proposed that long-lived memory T cells generated by vaccination or infection reside within a
memory compartment that has a finite size. Consequently, in a variety of acute infection models interclonal
competition has been shown to lead to attrition of preexisting memory CD8 T cells. Contrary to expectations,
therefore, we found that chronic Leishmania donovani infection of Listeria-immune mice results in heightened
protection against subsequent Listeria challenge. This protection was associated with bystander expansion of
Listeria-specific CD8 T cells and a bias in these cells toward a central memory T-cell phenotype with an
enhanced capacity for gamma interferon production. We propose that splenomegaly, which is characteristic of
visceral leishmaniasis and other tropical infections, may help promote heterologous immunity by resetting the
size of the memory compartment during chronic infection.
Memory CD8 -T-cell responses play an essential role in

  

Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia

 

Collections: Biotechnology