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This essay has been reproduced from the

Summary: This essay has been
reproduced from the
Great Experiments
section of
Gene Targeting: Altering the
Genome in Mice
Mario Capecchi
Gene targeting provides the means to create
strains of mice with specific mutations in
virtually any gene. This methodology permits
evaluation of the functions of genes in an
intact mammal and systematic genetic
dissection of the most complex biological
processes, such as development, learning
and immunity. The primary problem in
developing gene targeting was how to
generate a specific mutation in a mammalian
cell without altering any other site in the
genome. This became possible when we


Source: Alvarado, Alejandro Sánchez - Department of Neurobiology and Anatomy, University of Utah


Collections: Biology and Medicine