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Summary: Author's personal copy
Kinetochores' gripping feat:
conformational wave or biased
diffusion?
Charles L. Asbury1
, Jerry F. Tien2
and Trisha N. Davis2
1
Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
2
Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
Climbing up a cliff while the rope unravels underneath
your fingers does not sound like a well-planned adven-
ture. Yet chromosomes face a similar challenge during
each cell division. Their alignment and accurate segre-
gation depends on staying attached to the assembling
and disassembling tips of microtubule fibers. This cou-
pling is mediated by kinetochores, intricate machines
that attach chromosomes to an ever-changing microtu-
bule substrate. Two models for kinetochore-microtubule
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