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Summary: INFERRING FUNCTIONAL CONNECTIVITY USING SPATIAL MODULATION MEASURES
OF FMRI SIGNALS WITHIN BRAIN REGIONS OF INTEREST
Bernard Ng1
, Rafeef Abugharbieh1
, Martin J. McKeown2
1
Department of Electrical and Computer Engineering,
2
Department of Medicine (Neurology), Pacific Parkinson's Research Center,
University of British Columbia, Vancouver, BC, Canada, bernardn@ece.ubc.ca
ABSTRACT
We propose inferring functional connectivity between brain
regions by examining the spatial modulation of the blood
oxygen level dependent (BOLD) signals within brain regions
of interest (ROIs). This is motivated by our previous work,
where the spatial distribution of BOLD signals within an
ROI was found to be modulated by task. Applying replicator
dynamics to our proposed spatial feature time courses on
real functional magnetic resonance imaging (fMRI) data
detected task-related changes in the composition of the
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