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Summary: 3-D Reconstruction of Tumor Vascular Networks
Most solid tumors consist of optically dense tissue. Therefore
intravital visualization of its complete vasculature with
topological and morphological details is difficult. We propose a
method to reconstruct tumor vascular networks using confocal
intravital microscopy and a dedicated software system.
INTRODUCTION VASCULAR MIDLINES INITIALIZATION
CONCLUSION
Reconstruction of tumor vascular networks in
optically dense tissue with disorganized
topology is possible using semi-automatic
software. This application provides a useful
tool to help understanding the mechanisms of
tumor angiogenesis and tumor growth.
University Medicine Berlin Duke University Medical Center
S. Prohaska1, M. Dreher3, M.W. Dewhirst3, A. Chilkoti3 A.R. Pries2, M. Westerhoff1, A.J.M. Cornelissen2
1Zuse Institute Berlin, Germany; 2Department of Physiology Charité University Medicine Berlin, Germany; 3Duke University Medical Center, USA
Zuse Institute Berlin
AMIRA
· 3D Visualization
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