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The Thyrotropin -Subunit Gene Is Repressed by Thyroid Hormone in a Novel Thyrotrope Cell Line,
 

Summary: The Thyrotropin -Subunit Gene Is Repressed by
Thyroid Hormone in a Novel Thyrotrope Cell Line,
Mouse T T1 Cells*
BERNARDO YUSTA, ELAINE T. ALARID§, DAVID F. GORDON,
E. CHESTER RIDGWAY, AND PAMELA L. MELLON
Departments of Reproductive Medicine and Neurosciences and the Center for Molecular Genetics,
University of California-San Diego (B.Y., E.T.A., P.L.M.), La Jolla, California 92093-0674;
and the Department of Medicine, University of Colorado Health Sciences Center (D.F.G., E.C.R.),
Denver, Colorado 80262
ABSTRACT
TSH is expressed in two populations of thyrotropes in the pituitary:
one in the pars distalis and a second in the pars tuberalis. Pars distalis
thyrotropes exhibit classical endocrine inhibition of TSH by thyroid
hormone, whereas pars tuberalis thyrotropes do not. The majority of
our understanding of TSH subunit gene regulation has come from
studies conducted in dispersed pituitary, dispersed thyrotropic tu-
mors, or the GH3 somatolactotrope cell line. However, the dispersed
pituitary model is limited because of its inherent heterogeneity, thy-
rotropic tumors are difficult to grow and maintain, and the GH3 cells
lack endogenous TSH expression. The recent derivation of a clonal

  

Source: Alarid, Elaine T. - Molecular and Cellular Pharmacology Training Program & Department of Oncology,University of Wisconsin at Madison

 

Collections: Biology and Medicine