Summary: © The Rockefeller University Press, 0021-9525/99/10/7/6 $5.00
The Journal of Cell Biology, Volume 147, Number 1, October 4, 1999 7­12
http://www.jcb.org 7
Brief Report
ADP-ribosylation Factor 6 and Endocytosis at the Apical Surface of
Madin-Darby Canine Kidney Cells
Y. Altschuler,* S.-H. Liu,
L. Katz,* K. Tang,* S. Hardy, F. Brodsky,
G. Apodaca,§
and K. Mostov*
*Department of Anatomy, University of California, San Francisco, California 94143-0452;
G.W. Hooper Foundation,
Department of Microbiology and Immunology, Department of Biopharmaceutical Sciences, and Department of Pharmaceutical
Chemistry, University of California, San Francisco, California 94143-0552; §
Renal-Electrolyte Division, Department of
Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261; and Cell Genesis, Foster City, California 94404
Abstract. We report that the small GTPase,ADP-ribo-
sylation factor 6 (ARF6), is present only on the apical
surface of polarized MDCK epithelial cells. Overex-
pression of a mutant of ARF6,ARF6­Q67L, which is

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

Collections: Biology and Medicine