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ORIGINAL INVESTIGATION Lauren A. Weiss Mark Abney Rodney Parry
 

Summary: ORIGINAL INVESTIGATION
Lauren A. Weiss Mark Abney Rodney Parry
Angelo M. Scanu Edwin H. Cook Jr Carole Ober
Variation in ITGB3 has sex-specific associations with plasma
lipoprotein(a) and whole blood serotonin levels
in a population-based sample
Received: 15 September 2004 / Accepted: 14 December 2004 / Published online: 15 April 2005
Springer-Verlag 2005
Abstract A recent genome-scan identified the Leu33Pro
polymorphism in the b3 integrin (ITGB3) gene as a
quantitative trait locus for whole blood serotonin level
in a large Hutterite pedigree. Because both the Leu33Pro
polymorphism and the serotonin system have been
implicated in cardiovascular disease (CVD) risk and
treatment response, we studied additional variation in
ITGB3 and its relationship to intermediate phenotypes
associated with CVD in the same population. We
examined associations between 15 single nucleotide
polymorphisms (SNPs) across ITGB3 and five CVD-
related traits in the Hutterites: plasma levels of high

  

Source: Abney, Mark - Department of Human Genetics, University of Chicago

 

Collections: Computer Technologies and Information Sciences; Biology and Medicine