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The Requirement of Presynaptic Metabotropic Glutamate Receptors for the Maintenance of Locomotion
 

Summary: The Requirement of Presynaptic Metabotropic Glutamate
Receptors for the Maintenance of Locomotion
Michiko Takahashi1 and Simon Alford2
1Department of Physiology, Northwestern University Medical School, Chicago, Illinois 60611, and 2Department of
Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607
Spinal circuits known as central pattern generators maintain
vertebrate locomotion. In the lamprey, the contralaterally alter-
nating ventral root activity that defines this behavior is driven by
ipsilateral glutamatergic excitation (Buchanan and Grillner,
1987) coupled with crossed glycinergic inhibition (Buchanan,
1982; Alford and Williams, 1989). These mechanisms are dis-
tributed throughout the spinal cord. Glutamatergic excitatory
synapses activate AMPA and NMDA receptors known to be
necessary for the maintenance of the locomotor rhythm. Less is
known of the role and location of metabotropic glutamate
receptors (mGluRs), although group I mGluRs enhance trans-
mitter release at giant synapses in the lamprey spinal cord,
whereas group II/III receptors may inhibit release. In this study
we show that group I mGluR antagonists block fictive locomo-
tion, a neural correlate of locomotion, by acting at the presyn-

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collections: Biology and Medicine