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Proc. Natl. Acad. Sci. USA Vol. 94, pp. 32743278, April 1997
 

Summary: Proc. Natl. Acad. Sci. USA
Vol. 94, pp. 32743278, April 1997
Medical Sciences
Prevention of insect-borne disease: An approach using transgenic
symbiotic bacteria
RAVI V. DURVASULA*, ANDREW GUMBS*, ANIL PANACKAL*, OLEG KRUGLOV*, SERAP AKSOY*,
R. BRUCE MERRIFIELD, FRANK F. RICHARDS*, AND CHARLES B. BEARD
*Yale University School of Medicine, New Haven, CT 06520; The Rockefeller University, New York, NY 10021-6399; and Division of Parasitic Diseases,
National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724
Contributed by R. Bruce Merrifield, January 21, 1997
ABSTRACT Expression of molecules with antiparasitic
activity by genetically transformed symbiotic bacteria of dis-
ease-transmitting insects may serve as a powerful approach to
control certain arthropod-borne diseases. The endosymbiont
of the Chagas disease vector, Rhodnius prolixus, has been
transformed to express cecropin A, a peptide lethal to the
parasite, Trypanosoma cruzi. In insects carrying the trans-
formed bacteria, cecropin A expression results in elimination
or reduction in number of T. cruzi. A method has been devised
to spread the transgenic bacteria to populations of R. prolixus,

  

Source: Aksoy, Serap - School of Public Health, Yale University

 

Collections: Biology and Medicine